Mostly as connectors: N에도 불구하고 · -(으)ㅁ에도 불구하고
despite, in spite of (lit. to disregard)
Example
비가 오는데도 불구하고 많은 사람이 모였어요.
Despite the rain, many people gathered.
Word parts
불 not+구 restrain
Literally 'not restrained by'; something doesn't stop the result.
Good to know
Almost always appears as 에도 불구하고 'in spite of'; it rarely stands alone.